2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-142217S
    Quetiapine dimer impurity-d8
    Quetiapine dimer impurity-d8 is the deuterium labeled Quetiapine dimer impurity.
    Quetiapine dimer impurity-d<sub>8</sub>
  • HY-172744
    α-Hydroxy bromazolam
    α-Hydroxy bromazolam is a metabolite of Bromazolam catalyzed by CYP enzymes and can be found in plasma and urine. α-Hydroxy bromazolam is an important biomarker for Bromazolam intake.
    α-Hydroxy bromazolam
  • HY-N7080R
    Dihydroferulic acid (Standard)
    Dihydroferulic acid (Standard) is the analytical standard of Dihydroferulic acid. This product is intended for research and analytical applications. Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid is a metabolite of human gut microflora as well as a precursor of vanillic acid[1][2].
    Dihydroferulic acid (Standard)
  • HY-13256AS1
    Desmethyl Erlotinib-d4-1
    Desmethyl Erlotinib-d4-1 (OSI-420-d4-1 (free base); CP-373420-d4-1) is deuterium-labeled Desmethyl Erlotinib (HY-13256A).
    Desmethyl Erlotinib-d<sub>4</sub>-1
  • HY-W747910A
    S584 dihydrochloride
    S584 dihydrochloride is a catechol metabolite of the oral-effective Piribedil (HY-12707), with anti-lipid peroxidation activity. S584 dihydrochloride significantly inhibits lipid peroxidation in rat synaptosomes under basal conditions and Fe³⁺ stimulation. S584 dihydrochloride significantly antagonizes the increase in thiobarbituric acid reactive substances (TBARS) in the brains of mice exposed to high oxygen and under normal air conditions.
    S584 dihydrochloride
  • HY-W009538S1
    5'-Deoxy-5-fluorocytidine-13C5
    5'-Deoxy-5-fluorocytidine-13C5 is the 13C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer.
    5'-Deoxy-5-fluorocytidine-<sup>13</sup>C<sub>5</sub>
  • HY-138813R
    N-Desethyl Sunitinib hydrochloride (Standard)
    Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC).
    N-Desethyl Sunitinib hydrochloride (Standard)
  • HY-23331S
    Propylene thiourea-d3
    4-Methylimidazolidine-2-thione-d3 (4-Methylimidazolidine-2-thione-d3) is deuterium labeled 4-Methylimidazolidine-2-thione. Propylene thiourea is one of the main degradation products of Propineb (HY-119630) in animals, plants and during processing.
    Propylene thiourea-d<sub>3</sub>
  • HY-175141
    α-Hydroxy clonazolam
    α-Hydroxy clonazolam is a benzodiazepine metabolite.
    α-Hydroxy clonazolam
  • HY-N4173R
    8-Oxoepiberberine (Standard)
    p-Dimethylaminobenzaldehyde (Standard) is the analytical standard of p-Dimethylaminobenzaldehyde. This product is intended for research and analytical applications. p-Dimethylaminobenzaldehyde (4-Dimethylaminobenzaldehyde) is an organic compound containing amine and aldehyde moieties which is used in Ehrlich's reagent and Kovac's reagent to test for indoles.
    8-Oxoepiberberine (Standard)
  • HY-N0384S5
    Homovanillic acid-13C,d3
    Homovanillic acid-13C,d3 (Vanilacetic acid-13C,d3) is 13C and deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency.
    Homovanillic acid-<sup>13</sup>C,d<sub>3</sub>
  • HY-135910S
    3,4-Dehydro Cilostazol-d11
    3,4-Dehydro Cilostazol-d11 is deuterated labeled 3,4-Dehydro Cilostazol (HY-135910). 3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study.
    3,4-Dehydro Cilostazol-d<sub>11</sub>
  • HY-12983B
    ALS-8112-TP
    ALS-8112-TP is the 5'-triphosphate metabolite of ALS-8112 (HY-12983). ALS-8112-TP is a potent, selective and competitive respiratory syncytial virus (RSV) RNA polymerase inhibitor, with selectivity against polymerases from host or viruses unrelated to RSV such as hepatitis C virus (HCV). ALS-8112-TP can be efficiently recognized by the recombinant RSV polymerase complex, causing chain termination of RNA synthesis. ALS-8112-TP can be used for RSV-infection research.
    ALS-8112-TP
  • HY-127118A
    Pteropterin monohydrate
    Pteropterin (Pteroyltriglutamic) monohydrate is an active form of folate. Pteropterin monohydrate shows inhibiting effect on tumor growth and has broad anticancer activity.
    Pteropterin monohydrate
  • HY-133981
    Desmethylene tadalafil
    Desmethylene tadalafil is a metabolite of Tadalafil (HY-90009A). The formation of Desmethylene tadalafil mediated predominantly by CYP3A4.
    Desmethylene tadalafil
  • HY-175098
    (±)14(15)-DiHETE
    (±)14(15)-DiHETE, an oxylipin, is a metabolite of Eicosapentaenoic Acid (HY-B0660). Eicosapentaenoic Acid is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA).
    (±)14(15)-DiHETE
  • HY-137386
    2-Oxo-3-hydroxy-LSD
    2-Oxo-3-hydroxy-LSD is a metabolite of Lysergic acid diethylamide.
    2-Oxo-3-hydroxy-LSD
  • HY-167770
    Chrysin 7-sulfate
    Chrysin 7-sulfate is a conjugated metabolite of Chrysin (HY-14589). Chrysin 7-sulfate can strongly displace the Site I marker warfarin from human serum albumin. Chrysin 7-sulfate can effectively displace Ochratoxin A (OTA) (HY-N6788) from albumin both in vitro and in vivo.
    Chrysin 7-sulfate
  • HY-12771S2
    O-Desmethyl mebeverine acid-d6
    O-Desmethyl Mebeverine acid-d6 is deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl mebeverine acid-d<sub>6</sub>
  • HY-101671R
    S-methyl-KE-298 (Standard)
    S-methyl-KE-298 (Standard) is the analytical standard of S-methyl-KE-298. This product is intended for research and analytical applications. S-methyl-KE-298 is an active metabolite of KE-298. KE-298 inhibits matrix metalloproteinase (MMP-1) production from rheumatoid arthritis (RA) synovial cells.
    S-methyl-KE-298 (Standard)
Cat. No. 상품명 / Synonyms Application Reactivity